CPHON Chemotherapy Practice Test

These questions are part of the practice quiz. Start practicing

• Rituximab is directed against which antigen?
• Which statement best describes protocol compliance in clinical trials?
• Progressive disease (PD) is defined as?
• Which plays a pivotal role in the body's lymphocyte immune response?
• Which of the following is listed as a common route of exposure to chemotherapy agents?
• What is a key reason for obtaining informed consent in a clinical trial?
• Via which route is vincristine given?
• Which statement is correct regarding daunorubicin and cardiotoxicity?
• What is the recommended practice for flushing and maintaining a central venous catheter during chemotherapy?
• In pediatric chemotherapy care, what is the purpose of involving a dietitian?
• Nursing care priorities for the child with symptoms of SIADH include:
• Which of the following is the most important practice to prevent exposure to health care workers?
• In phase III cancer trials, what is the primary objective?
• Which statement best describes late effects of cancer therapy?
• In a Phase I clinical trial, which outcome is primarily evaluated to determine safety?
• How should mercaptopurine dosing be adjusted in a patient with TPMT deficiency?
• Bleomycin is notably associated with toxicity to which organ system?
• TLS prophylaxis aims to prevent which complication?
• Which statement accurately describes intrathecal administration in this context?
• Which statement is true regarding initial signs and symptoms of childhood cancer?
• The immediate temperature application for a Doxorubicin/Daunorubicin extravasation involves:
• Which of the following is a basic required element in the informed consent document?
• What are typical platelet transfusion thresholds in a stable pediatric chemotherapy patient?
• Cisplatin carries a well-known risk of ototoxicity, which is commonly monitored with baseline audiometry.
• What steps ensure safe drug administration for immunocompromised pediatric patients during hospitalization?
• During the 1970s, which type of therapy was found to improve response rates and survival without significantly increasing toxicity?
• Which chemo agent is associated with a maximum cumulative lifetime dose?
• L-Asparaginase is classified as which type of agent?
• Which statement best describes the typical pattern of chemotherapy-induced peripheral neuropathy?
• What is the immediate management for suspected vesicant extravasation of a chemotherapy drug?
• Which PPE configuration is considered optimal during chemotherapy administration and when handling bodily fluids?
• Mercaptopurine is classified as which type of chemotherapeutic agent?
• Which practice best prevents chemotherapy dosing errors?
• What is a major pulmonary toxicity associated with bleomycin, and what monitoring is recommended?
• Which Belmont Report principle focuses on fairness in distributing research burdens and benefits?
• Which combination of electrolyte disturbances is most characteristic of tumor lysis syndrome?
• How should chemotherapy dosing be adjusted in a patient with significant renal or hepatic impairment?
• Which diagnostic test would you order prior to daunorubicin administration to assess cardiac function?
• Early therapeutic doses of radiation were chosen based on the skin reaction expected. Which outcome was used to estimate those doses?
• Intrathecal methotrexate in pediatric leukemia is used for what purpose, and what is key about dosing?
• Compare the principal toxicities of cisplatin and carboplatin.
• Which immunoglobulin causes secretion of histamines, leukotrienes and prostaglandins during a hypersensitivity reaction?
• In assessing adherence, which statement is true?
• Which statement best describes what a vesicant is?
• What preventive measure reduces bladder toxicity with cyclophosphamide?
• Which infusion is titrated up to achieve the prescribed dose?
• Based on Kayla's case of a brain tumor treated with surgery, chemotherapy, and radiation, which statement is most accurate?
• Rituximab binds to the CD20 antigen on B cells. Which cell type is primarily affected?
• Chemo administered to treat CNS disease is delivered via which route?
• Vincristine toxicity most commonly affects which body system?
• Why is mesna given with ifosfamide therapy?
• Which chemotherapy agent is most commonly associated with hypomagnesemia?
• To perform clinical trials, researchers must be compliant with federal guidelines established by the FDA. The guidelines require that all research be approved by:
• Important lab values to check prior to the administration of asparaginase include platelets and:
• Most monoclonal antibodies used in therapy target which class of immunoglobulins?
• Which statement best describes assent in pediatric chemotherapy?
• After administering the first drug for a dermatologic reaction after peg-Asparaginase, Sam starts to complain of throat tightening and he starts wheezing. The MD orders Epinephrine. What is the preferred route?
• Which body is primarily responsible for approving clinical trial protocols to protect human subjects?
• Cumulative dose of which class of chemotherapy agents should be monitored?
• What is the purpose of informed consent in a clinical trial?
• Baseline studies for children receiving anthracyclines should include:
• Which is the correct sequence of phases as the cell enters the cell cycle?
• How does weight measurement influence chemotherapy dosing in pediatric patients?
• In suspected tumor lysis syndrome, which IV fluid strategy is anticipated to support renal excretion of metabolites?
• Pharmacogenetics studies inherited differences in metabolism and effect; which option best describes this concept?
• Which chemotherapy-related mucositis care strategy is most effective for children?
• How is pharmacokinetics defined?
• Which document approves research involving human subjects?
• What is the major neurotoxic effect of vincristine in pediatric patients and how should it be assessed?
• In febrile neutropenia management, under what condition is patient isolation typically implemented?
• Capillary leak syndrome is most likely to develop following the administration of which agent?
• Which test is used to assess hearing when there is a concern for ototoxicity from cisplatin therapy?
• Which agent is used to prevent hemorrhagic cystitis when administering cyclophosphamide?
• What special consideration is required before using rasburicase in TLS?
• During high-dose methotrexate therapy, which laboratory and organ-function tests are essential to monitor?
• John is a 3-year-old who is scheduled to receive his first subQ injection of Neupogen. What would NOT be an appropriate strategy to decrease the pain associated with a SC injection?
• Carboplatin dosing using the Calvert formula includes which parameter?
• Chemo for osteogenic sarcoma can be administered by which route?
• Which statement about late effects of chemotherapy is true?
• Cancer treatment may also cause secondary malignant neoplasms. Which agent has been linked to later development of Acute Myeloid Leukemia (AML) and myelodysplastic syndrome (MDS)?
• Which factor increases the risk of cardiotoxicity with doxorubicin therapy?
• In a Phase I trial, what must be verified first before administering the investigational agent?
• When is growth factor (G‑CSF) support generally considered in pediatric chemotherapy?
• How should imatinib be taken for optimal absorption?
• Which statement best describes the earliest skin reaction associated with initial radiation therapy dosing?
• What is tumor lysis syndrome and what are the key preventive measures in a high‑risk child receiving chemotherapy?
• Progressive disease is defined as greater than what percentage increase in tumor burden or appearance of a new tumor?
• Which oncogene is commonly amplified in neuroblastoma?
• Protective gloves should be discarded after how many minutes of wear?
• In anaphylaxis due to peg-Asparaginase, what is the preferred route for epinephrine administration?
• Which presenting sign is most characteristic of neuroblastoma in a child?
• What is the primary purpose of intrathecal chemotherapy in pediatric patients?
• Which statement about TLS prophylaxis is correct?
• Which of the following is given to prevent hypersensitivity reactions?
• For patients receiving bleomycin, which complication is most likely?
• Which of the following is an incorrect statement when providing information to caregivers regarding administering chemo in the home?
• Which of the following is a characteristic of malignant cells?
• For high-emetogenic risk regimens, which antiemetic addition may be used beyond ondansetron and dexamethasone?
• Which statement about methotrexate and pulmonary toxicity is true?
• Which measure is essential to promote clearance of methotrexate during high-dose therapy?
• During high-dose methotrexate therapy, which medication should be discontinued?
• Which chemo agent is commonly associated with hemorrhagic cystitis?
• Pharmacogenetics refers to the:
• Which agent is a cell-cycle specific antimetabolite?
• During high-dose methotrexate therapy, which organ pairs are monitored for toxicity?
• Which trio of ethical principles comprises the Belmont Report?
• How should a pediatric oncology nurse respond to a suspected chemotherapy overdose?
• Before administering vincristine, which nursing assessment is essential to monitor for potential neurotoxicity?
• Which statement about cumulative dosing in chemotherapy is correct?
• Which of the following is a cell-cycle specific chemotherapy agent?
• In pediatric oncology, what are the core steps in managing febrile neutropenia?
• What role does nutrition play in pediatric chemotherapy patient outcomes?
• Which formula is most commonly used to calculate a child’s body surface area (BSA) for dosing?
• Which chemo agent causes delayed nausea and vomiting?
• Intrathecal chemotherapy dosage is based on which parameter?
• It is important to monitor for late effects following chemo. After receiving Cisplatin, which body system will need to be monitored?
• Which statement describes rituximab infusion dosing?
• Which monitoring parameter is commonly checked to detect pancreatitis risk during L‑asparaginase therapy?
• Doxorubicin must be given within what timeframe relative to the start of the dexrazoxane infusion?
• Which intervention would be LEAST appropriate when supporting hospitalized young adults?
• During the inflammatory stage of an infection, the first granulocyte to arrive at the site of inflammation is the?
• Which is the most appropriate safe-handling practice when caring for a child who received chemo within the last 24 hours?
• Which toxicities are commonly associated with L‑asparaginase and warrant monitoring?
• What is the role of hand hygiene and PPE in preventing hospital-acquired infections for immunocompromised pediatric patients?
• Chemo-approved gloves are not required when which activity?
• Which parameter is essential to monitor hydration status during high-dose methotrexate therapy?
• In high-dose methotrexate therapy, leucovorin rescue is used to restore healthy cells. Which option best describes this purpose?
• Which of the following is a core ethical principle addressed by the Belmont Report?
• Which statement best defines histocompatibility leukocyte antigens (HLA)?
• ANC is typically expressed in which unit?
• Which class of chemotherapy agents includes drugs for which cumulative dose monitoring is especially important due to cardiotoxicity risk?
• Which pairing of chemotherapy agent and monitoring is correct?
• A Nuremberg Code was the first document written to address:
• A child with symptoms of SIADH is most likely to present with which electrolyte abnormality?
• Which statement best describes the primary goal of phase II clinical trials in oncology when evaluating a new agent?
• Which vaccine considerations are important for pediatric patients undergoing chemotherapy?
• Prior to starting multimodal chemotherapy for osteosarcoma, which diagnostic test is NOT routinely indicated to establish baseline organ function?
• During the administration of etoposide, the patient should be closely monitored for:
• Which of the following is NOT part of the pre-asparaginase lab panel described?
• Which statement best defines late effects in the context of cancer therapy?
• Which route is used to deliver chemotherapy directly into the central nervous system to treat brain tumors?
• Which of the following is a common side effect caused by vincristine?
• What is the most common route for initial chemotherapy administration in pediatric oncology, and why is it preferred?
• Which of the following is NOT a basic required element in informed consent?
• What central venous access device is commonly used for long‑term pediatric chemotherapy to facilitate frequent dosing and vesicant administration?
• While hanging an IV chemo bag, the bag disconnects and spills; what is your first action?
• What is the importance of assent and consent in pediatric chemotherapy treatment?
• Which agent is commonly associated with transient diarrhea in chemotherapy?
• Which blood cell type, when decreased, is associated with increased infection risk?
• To minimize the risk of pulmonary toxicity from bleomycin, what is the recommended approach to oxygen exposure?
• The goal of a phase I clinical trial is to determine:
• You are giving Doxorubicin peripherally IV push and based on the patient's complaints and loss of blood return, you suspect that the Doxorubicin has extravasated. Your immediate nursing intervention will involve:
• Which agent commonly causes transient early diarrhea?
• Where do B cells mature?
• Which action is NOT an immediate intervention for doxorubicin extravasation?
• Which route is used to deliver chemotherapy directly into the cerebrospinal fluid?
• Which of the following is a red flag that would prompt a red blood cell transfusion in a pediatric chemo patient?
• PPE is not required in which scenario?
• In TLS prevention, which uric acid–lowering therapy rapidly reduces uric acid levels and is used in high‑risk patients?
• Which TLS management agent rapidly lowers uric acid levels and requires consideration of G6PD deficiency when used?
• Before a patient is to receive intrathecal chemotherapy, which precaution is essential?
• What electrolyte disturbances characterize tumor lysis syndrome?
• If a nurse is administering IV chemotherapy and the IV line leaks, who is responsible for containing the spill?
• Which administration route is used to deliver chemotherapy to treat central nervous system disease?
• Which Chemo agent is associated with a high risk for hypersensitivity reaction?
• Which of the following is a commonly observed adverse reaction that occurs during a rituximab infusion?
• Risk factors that may influence the development of late effects include all of the following except:
• Which antiemetic combination is commonly used for pediatric chemotherapy‑induced nausea and vomiting?
• Which drug is a classic antimetabolite used in leukemia treatment?
• In case of suspected chemotherapy overdose, which sequence is appropriate?
• In phase I trials, which objective is typically sought?
• Which electrolyte abnormality is characteristic of tumor lysis syndrome?
• Which intervention is appropriate for a patient receiving thiotepa?
• How is the absolute neutrophil count (ANC) calculated?
• Which option correctly identifies a safety measure to prevent chemotherapy dosing errors?
• Which Belmont Report principle emphasizes informed consent and treating individuals as autonomous agents?
• Which of the following is a potential reaction to cytarabine?
• Allopurinol functions in TLS prevention by inhibiting xanthine oxidase to reduce uric acid production. Which statement is true?
• The preferred intramuscular site for a child who is three-years-old and walks is:
• What is the rationale for limiting lifetime cumulative doxorubicin exposure and how is it monitored?
• What is a major safety concern with vincristine administration and what explicit precaution is required?
• A 2-year-old receiving Vincristine shows signs of peripheral neuropathy. Which symptoms may indicate this side effect?
• Why is TPMT testing important before starting 6‑mercaptopurine in pediatric oncology?
• What is the first essential step in handling a chemotherapy spill?
• Which drug has notable cardiotoxic potential that necessitates a baseline echocardiogram before use?
• Which is most effective distraction technique to reduce pain during pediatric subcutaneous injections?
• Peripheral neuropathy is usually:
• What urine output rate is targeted to help prevent methotrexate-related nephrotoxicity?
• Which statement best describes a cell cycle–specific chemotherapeutic agent?
• Which statement best describes the nursing assessment for patency with a direct-push method of administering a chemotherapy vesicant?
• What two organs are closely monitored when a patient is receiving high dose methotrexate?
• The initial action in the event of accidental eye contact with a cytotoxic agent is:
• Carboplatin dosing using the Calvert formula requires monitoring which parameter as part of protocol?
• Which of the following is a monoclonal antibody used in cancer therapy?
• Meghan, a 7-year-old with a brain tumor, recently received cisplatin and has ongoing nausea and vomiting five days later. Which statement is most likely true?
• Which baseline assessment is commonly performed before starting chemotherapy in a pediatric patient?
• Which oral preparation contains aspartame and should be used with caution in children with phenylketonuria?
• Which symptom is least typical as a presenting sign of childhood leukemia?
• What are the key cardiac safety considerations with anthracyclines like doxorubicin?
• Which of the following represents the Belmont Report’s ethical principle related to ensuring participants' protection and rights?
• Which federal agency requires health care facilities to maintain policies for the safe handling of chemotherapy agents?
• Which statement regarding tumor markers in childhood cancers is true?
• Which of the following is a common adverse reaction during a rituximab infusion?
• Which chemotherapy agent is associated with mucositis as a potential reaction?
• Among vinca alkaloids, which is more likely to cause severe bone marrow suppression?