Which of the following is a common side effect caused by vincristine?

• A. Weight gain
• B. Jaw pain
• C. Cardiac toxicity
• D. Respiratory distress

Answer: (B)

Vincristine commonly causes neurotoxicity, which can manifest as nerve-related symptoms and muscle discomfort. One well-recognized and particularly common manifestation, especially in children, is jaw pain. The drug’s effect on nerve fibers and muscles can lead to jaw stiffness or discomfort, sometimes described as difficulty opening the mouth or jaw muscle spasm. This side effect is more characteristic of vincristine than other listed reactions, and it’s typically managed with supportive care such as gentle jaw exercises, warmth, and analgesia if needed.

In contrast, weight gain is not a typical side effect of vincristine, and cardiac toxicity or respiratory distress are not characteristic adverse effects of this drug. Those symptoms would more strongly point to other agents or complications.