Rituximab is directed against which antigen?

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Prepare for the CPHON Chemotherapy Test with interactive materials. Use flashcards and multiple choice questions with hints and explanations. Get exam-ready!

Multiple Choice

Rituximab is directed against which antigen?

Explanation:
Rituximab binds to CD20, a protein on the surface of mature B cells. By attaching to CD20, it flags these B cells for destruction through immune mechanisms such as complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity, and it can directly trigger B-cell death. Because CD20 is present on most mature B cells but not on hematopoietic stem cells or plasma cells, this approach can deplete B cells while allowing normal immune recovery later. Other antigens listed are not targets of rituximab: CD45 is a common leukocyte marker found on many white cells, CD33 is a myeloid marker, and CD54 (ICAM-1) is an adhesion molecule. Rituximab’s action is specifically tied to CD20 on B cells.

Rituximab binds to CD20, a protein on the surface of mature B cells. By attaching to CD20, it flags these B cells for destruction through immune mechanisms such as complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity, and it can directly trigger B-cell death. Because CD20 is present on most mature B cells but not on hematopoietic stem cells or plasma cells, this approach can deplete B cells while allowing normal immune recovery later.

Other antigens listed are not targets of rituximab: CD45 is a common leukocyte marker found on many white cells, CD33 is a myeloid marker, and CD54 (ICAM-1) is an adhesion molecule. Rituximab’s action is specifically tied to CD20 on B cells.

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