In case of suspected chemotherapy overdose, which sequence is appropriate?

• A. Document the event and continue the infusion.
• B. Stop the infusion, monitor vital signs, and consult the pharmacist.
• C. Delay action until a physician arrives.
• D. Stop the infusion, assess the patient, verify drug and dose, notify the physician, initiate protocol-based supportive care, and document actions.

Answer: (D)

In a suspected chemotherapy overdose, the priority is a rapid, structured response that prevents further exposure and starts appropriate treatment right away. The best sequence is to stop the infusion immediately to stop the drug from continuing to enter the patient. Then perform a quick but thorough patient assessment—check vital signs, monitor for symptoms, and assess airway, breathing, and circulation. Next, verify the drug and the dose to confirm what was given and catch any dosing or administration errors that could guide the treatment plan. After verification, notify the physician to obtain orders and activate any institutional overdose protocol. Finally, initiate protocol-based supportive care and document every action and observation.

This approach is safer than continuing the infusion, delaying action until someone arrives, or skipping the verification and physician notification steps, all of which can allow harm to progress and delay effective treatment.