Chemo for osteogenic sarcoma can be administered by which route?

• A. Intraperitoneal
• B. Intravesicular
• C. Intrathecal
• D. Intra-arterial

Answer: (B)

The key idea is delivering chemotherapy directly to the tumor site to maximize local drug exposure. For an osteogenic sarcoma in the limb, infusing the drug through the artery that feeds the tumor lets a high concentration reach the cancer cells in that area while reducing overall systemic exposure. This targeted intra-arterial approach can help shrink the tumor and support limb-sparing strategies, often in combination with systemic therapy.

Other routes target different areas: intravesicular delivery goes into the bladder, intrathecal into the spinal fluid, and intraperitoneal into the peritoneal cavity. Those are appropriate for cancers in those locations but don’t provide the high local concentrations needed for a bone tumor in the limb. Intravenous administration is systemic and spreads the drug throughout the body, which is important for micrometastases but does not concentrate the drug in the limb tumor as effectively as intra-arterial delivery.